Using python and pandas in the business world can be a very useful alternative to the pain of manipulating Excel files. While this combination of technologies is powerful, it can be challenging to convince others to use a python script - especially when many may be intimidated by using the command line. In this article I will show an example of how to easily create an end-user-friendly GUI using the Gooey library. This interface is based on wxWindows so it looks like a “native” application on Windows, Mac and Linux. Ultimately, I believe that presenting a simple user interface to your scripts can greatly increase the adoption of python in your place of business.